The parents of Annie McCann continue to seek answers.

Convinced that their 16-year-old daughter did not run away from her Virginia home of her own volition, and did not kill herself once she reached Baltimore by drinking Bactine, Daniel and Mary Jane McCann (at left, in a photo by The Sun's Amy Davis) are refusing to give up.

The couple have scheduled a news conference for Thursday to update the public on their private investigation. They say have "significant new developments" into the case but wouldn't divulge them to me on Wednesday.

As you might remember, Annie left home Oct. 31, leaving behind a note that said she had contemplated suicide but decided to run away instead. Her body was found two days later off Lombard Street east of the Inner Harbor. Her car was found dumped two blocks away.

The cases has had dozens of twists and turns, including youths who admitted to finding her body in the car, removing it to near a trash bin at a public housing complex and taking the car for a ride. There were other suicide notes, written and crossed out, found both at Annie's home and by her body. The Medical Examiner has ruled the cause of her death undetermined but said she overdoses on lidocaine from drinking a bottle of the antiseptic Bactine.

Did she drink it herself or did someone force her to down the bottle? The McCanns say the drug wasn't enough to kill her, that her note indicated she had changed her mind and was not a declaration of suicide, that she met at least two mysterious people in Baltimore. They are angry that Baltimore police shelved the investigation in March 2009, saying they're sure Annie took her own life.

It is not a conclusion the McCann's can live with. We'll have more have the news conference on Thursday.